Thank you Maryann for another inciteful article. I'd be interested in links to this and Reynaud's Disease. I believe Reynaud's mainly affects women and symptoms don't normally start till the onset of puberty - so estrogen must be linked. It's also hereditary. Also intrigued by potential covid links as I know a number of people developed circulatory issues - eg chilblains (am assuming that more micro- than macro circulation at play?)
Thanks! that's interesting — I'll look into Reynaud's disease. Yes, covid increases the risk of endothelial dysfunction which is involved in both large and small arteries (but microcirculation seems to be more of a factor). Here's a good review on the mechanisms https://www.nature.com/articles/s41401-022-00998-0
Interesting to me, after experimenting with methylene blue, which shows promise for brain cognition. The downside is, it suppresses “excess” estrogen and nitric oxide. Not a problem for a male in his twenties. But for myself at 62, it ruined my workouts and caused some issues that can only be chalked up to estrogen deficiency. Appreciate the info
It's so hard to know what to do when it comes to estrogen. I'm in my early 50's, still ovulating, and not peri-menopausal. I've been on OCP for decades (on and off) and worry about the impact on my endothelial function. I take bioflavonoids and eat a diet that promotes nitric oxide. I just wish we had access to better testing and accessibility. I can't even get MDs to order small particle LDL for my clients without a fight, so forget about having a discussion about endothelial function.
Thank you Maryann for another inciteful article. I'd be interested in links to this and Reynaud's Disease. I believe Reynaud's mainly affects women and symptoms don't normally start till the onset of puberty - so estrogen must be linked. It's also hereditary. Also intrigued by potential covid links as I know a number of people developed circulatory issues - eg chilblains (am assuming that more micro- than macro circulation at play?)
Thanks! that's interesting — I'll look into Reynaud's disease. Yes, covid increases the risk of endothelial dysfunction which is involved in both large and small arteries (but microcirculation seems to be more of a factor). Here's a good review on the mechanisms https://www.nature.com/articles/s41401-022-00998-0
Interesting to me, after experimenting with methylene blue, which shows promise for brain cognition. The downside is, it suppresses “excess” estrogen and nitric oxide. Not a problem for a male in his twenties. But for myself at 62, it ruined my workouts and caused some issues that can only be chalked up to estrogen deficiency. Appreciate the info
Wow, that's interesting. Will have to check it out. Thanks for sharing!
It's so hard to know what to do when it comes to estrogen. I'm in my early 50's, still ovulating, and not peri-menopausal. I've been on OCP for decades (on and off) and worry about the impact on my endothelial function. I take bioflavonoids and eat a diet that promotes nitric oxide. I just wish we had access to better testing and accessibility. I can't even get MDs to order small particle LDL for my clients without a fight, so forget about having a discussion about endothelial function.
I get it. There's a test called AMDA that is a good indicator, but no one would order it and it's probably very expensive.